Evaluation of clinical outcomes after partial horizontal laryngectomy
Daniel Abreu Rocha, Gustavo Fernandes de Alvarenga, Daniel Marin Ramos, Leandro Luongo de Matos, Rogerio Aparecido Dedivitis, Marco Aurélio Vamondes Kulcsar, Claudio Roberto Cernea
Abstract
Introduction: The laryngeal squamous cell carcinoma (LSCC) is a prevalent disease, with 7670 cases estimated in Brazil during 2018-2019. The preferred treatment for early LSCC is either surgery or radiotherapy. Horizontal partial laryngectomy (HPL) is one of the forms of surgical treatment. Objective: Evaluate the oncological and functional outcomes of patients submitted to HPL for the treatment of LSCC. Methods: A retrospective descriptive study of patients submitted to HPL, performed at a cancer referral center, between January 2011 and December 2017. Results: We evaluated 37 patients. The major pathological staging of the primary tumor was pT3 (35.1%), followed by pT2 (32.4%). Five patients required adjuvant radiotherapy; 62.2% of the patients were decannulated by the end of the treatment; 10.8% weren`t decannulated; 8.1% underwent a retracheostomy, and 18.9% had total laryngectomy. From the patients submitted to total laryngectomy, 3 cases were due to rehabilitation failure, 2 due to recurrence and 2 cases due to postoperative suture dehiscence. About 89% of the patients resumed oral feeding following the procedure; 86.4% didn`t present disease recurrence; 31 patients survived without disease; 3 died from disease-related causes, and 3 from unrelated causes. Conclusion: HPL is an alternative procedure to total laryngectomy, presenting adequate rates of local control and overall survival while also maintaining laryngeal function. The main challenge to HPL remains achieving an ideal selection of patients.
Keywords
References
1. Succo G, Crosetti E, Bertolin A, Lucioni M, Caracciolo A, Panetta V, Sprio AE, Berta GN, Rizzotto G. Benefits and drawbacks of open partial horizontal laryngectomies, Part A: early‐ to intermediate‐stage glottic carcinoma. Head Neck. 2016;38(Suppl 1):E333-40. http://dx.doi.org/10.1002/hed.23997. PMid:25581514.
2. Instituto Nacional de Câncer José Alencar Gomes da Silva. Coordenação de Prevenção e Vigilância. Estimativa 2018: incidência de câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2017. [cited 2019 June 24]. Available from: http://www1.inca.gov.br/estimativa/2018/
3. Succo G, Crosetti E. Limitations and opportunities in open laryngeal organ preservation surgery: current role of OPHLs. Front Oncol. 2019;9:408. http://dx.doi.org/10.3389/fonc.2019.00408. PMid:31192120.
4. Misono S, Marmor S, Yueh B, Virnig BA. Treatment and survival in 10,429 patients with localized laryngeal cancer: a population-based analysis. Cancer. 2014;120(12):1810-7. http://dx.doi.org/10.1002/cncr.28608. PMid:24639148.
5. Majer EH, Rieder W. Technic of laryngectomy permitting the conservation of respiratory permeability (cricohyoidopexy). Ann Otolaryngol. 1976;76:677-81. PMid:14420078.
6. Piquet JJ, Desaulty A, Decroix G. Crico-hyoido-epiglotto-pexy. Surgical technique and functional results. Ann Otolaryngol Chir Cervicofac. 1974;91(12):681-6.
7. Laccourreye H, Laccourreye O, Weinstein G, Menard M, Brasnu D. Supracricoid laryngectomy with cricohyoidopexy: a partial laryngeal procedure for selected supraglottic and transglottic carcinomas. Laryngoscope. 1990;100(7):735-41. http://dx.doi.org/10.1288/00005537-199007000-00009. PMid:2362533.
8. Laccourreye H, Laccourreye O, Menard M, Weinstein G, Brasnu D. Supracricoid laryngectomy with cricohyoidoepiglottopexy: a partial laryngeal procedure for glottic carcinoma. Ann Otol Rhinol Laryngol. 1990;99(6):421-6. http://dx.doi.org/10.1177/000348949009900601. PMid:2350125.
9. Schindler A, Pizzorni N, Mozzanica F, Fantini M, Ginocchio D, Bertolin A, Crosetti E, Succo G. Functional outcomes after supracricoid laryngectomy: what do we not know and what do we need to know? Eur Arch Otorhinolaryngol. 2016;273(11):3459-75. http://dx.doi.org/10.1007/s00405-015-3822-3. PMid:26545378.
10. Park JO, Joo YH, Cho KJ, Kim NG, Kim MS. Functional and oncologic results of extended supracricoid partial laryngectomy. Arch Otolaryngol Head Neck Surg. 2011;137(11):1124-9. http://dx.doi.org/10.1001/archoto.2011.182. PMid:22106237.
11. Zacharek MA, Pasha R, Meleca RJ, Dworkin JP, Stachler RJ, Jacobs JR, Marks SC, Garfield I. Functional outcomes after supracricoid laryngectomy. Laryngoscope. 2001;111(9):1558-64. http://dx.doi.org/10.1097/00005537-200109000-00012. PMid:11568604.
12. Spriano G, Pellini R, Romano G, Muscatello L, Roselli R. Supracricoid partial laryngectomy as salvage surgery after radiation failure. Head Neck. 2002;24(8):759-65. http://dx.doi.org/10.1002/hed.10117. PMid:12203801.
13. Sewnaik A, Hakkesteegt MM, Meeuwis CA, De Gier HHW, Kerrebijn JDF. Supracricoid partial laryngectomy with cricohyoidoepiglottopexy for recurrent laryngeal cancer. Ann Otol Rhinol Laryngol. 2006;115(6):419-24. http://dx.doi.org/10.1177/000348940611500604. PMid:16805372.
14. Nakayama M, Okamoto M, Hayakawa K, Ishiyama H, Kotani S, Miyamoto S, Seino Y, Okamoto T, Soda I, Sekiguchi A. Clinical outcome of supracricoid laryngectomy with cricohyoidoepiglottopexy: radiation failure versus previously untreated patients. Auris Nasus Larynx. 2013;40(2):207-10. http://dx.doi.org/10.1016/j.anl.2012.07.014. PMid:22889564.
15. Thomas L, Drinnan M, Natesh B, Mehanna H, Jones T, Paleri V. Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English language literature. Cancer Treat Rev. 2012;38(3):203-11. http://dx.doi.org/10.1016/j.ctrv.2011.05.010. PMid:21764220.
16. Pellini R, Pichi B, Ruscito P, Ceroni AR, Caliceti U, Rizzotto G, Pazzaia A, Laudadio P, Piazza C, Peretti G, Giannarelli D, Spriano G. Supracricoid partial laryngectomies after radiation failure: a multi‐institutional series. Head Neck. 2008;30(3):372-9. http://dx.doi.org/10.1002/hed.20709. PMid:17972314.
17. Amid MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, Jessup JM, Brierley JD, Gaspar LE, Schilsky RL, Balch CM, Winchester DP, Asare EA, Madera M, Gress DM, Meyer LR, editors, AJCC cancer staging manual. 4th ed. New York: Springer; 2018.
18. Succo G, Peretti G, Piazza C, Remacle M, Eckel HE, Chevalier D, Simo R, Hantzakos AG, Rizzotto G, Lucioni M, Crosetti E, Antonelli AR. Open partial horizontal laryngectomies: a proposal for classification by the working committee on nomenclature of the European Laryngological Society. Eur Arch Otorhinolaryngol. 2014;271(9):2489-96. http://dx.doi.org/10.1007/s00405-014-3024-4. PMid:24691854.
19. Pellini R, Pichi B, Ruscito P, Ceroni AR, Caliceti U, Rizzotto G, Pazzaia A, Laudadio P, Piazza C, Peretti G, Giannarelli D, Spriano G. Supracricoid partial laryngectomies after radiation failure: a multi‐institutional series. Head Neck. 2008;30(3):372-9. http://dx.doi.org/10.1002/hed.20709. PMid:17972314.
20. De Virgilio A, Greco A, Bussu F, Gallo A, Rosati D, Kim SH, Wang CC, Conte M, Pagliuca G, De Vincentiis M. Salvage total laryngectomy after conservation laryngeal surgery for recurrent laryngeal squamous cell carcinoma. Acta Otorhinolaryngol Ital. 2016;36(5):373-80. http://dx.doi.org/10.14639/0392-100X-749. PMid:27958597.
21. Borges MSD, Mangilli LD, Ferreira MC, Celeste LC. Apresentação de um protocolo assistencial para pacientes com distúrbios da deglutição. CoDAS. 2017;29(5):e20160222. http://dx.doi.org/10.1590/2317-1782/20172016222.
Facebook
Google+
Twitter
LinkedIn
Mendeley
StumbleUpon
CiteULike
Reddit
Email